IMR Press / EJGO / Volume 41 / Issue 6 / DOI: 10.31083/j.ejgo.2020.06.2185
Open Access Review
Primary endometrial carcinoma with signet-ring cells. A case report and review of the literature
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1 Department of Obstetrics & Gynecology of Miguel Servet University Hospital, 50009, Zaragoza, Spain
2 Department of Anatomic Pathology of Miguel Servet University Hospital, 50009, Zaragoza, Spain
Eur. J. Gynaecol. Oncol. 2020, 41(6), 879–883; https://doi.org/10.31083/j.ejgo.2020.06.2185
Revised: 1 July 2020 | Accepted: 5 August 2020 | Published: 15 December 2020
Abstract

Endometrial adenocarcinoma with signet-ring cells is an infrequent histological type of carcinoma that usually corresponds to a metastasis of a primary carcinoma of another origin, mainly from the gastrointestinal tract or the breast. For this reason, in view of this histological finding, it is essential to carry out a thorough evaluation including mammography, gastroscopy, colonoscopy and thoracoabdominopelvic CT. To date, only six cases of primary endometrial carcinoma with signet-ring cells have been reported in the English literature. A 73-year-old patient was referred to the Gynecology Department with a 3-day history of postmenopausal bleeding. She was diagnosed with primary endometrial adenocarcinoma with signet-ring cells. The anatomopathological special features of the surgical specimen are presented, as well as the evolution of the patient, who remained asymptomatic and free of disease 28 months after surgery. A review of the literature is performed, emphasizing the peculiarities of this rare histological subtype. Despite the fact that primary endometrial carcinoma with signet-ring cells is an infrequent tumor, it must be considered in the differential diagnosis of malignant tumors of aforesaid origin. It is essential to carry out a correct and an extensive investigative study as well as an immunohistochemical analysis of the samples obtained for its confirmation diagnosis.

Keywords
Endometrial adenocarcinoma
Signet-ring cells
Immunohistochemical analysis
Figures
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