Objective: Color Doppler ultrasound was used to evaluate the intraabdominal ovarian cancer tumor model in nude mice, to explore its diagnostic value on ovarian cancer in nude mice. Materials and Methods: A SKOV3 cell line was utilized to establish intraperitoneal implant tumor model of ovarian cancer in nude mice. The nude mice were divided into five groups,each group received different drugs. Color Doppler ultrasound was used to evaluate the size of intraabdominal tumor and its color Doppler blood flow. And the final pathological results were compared with the results of color Doppler ultrasound. Results: Color Doppler ultrasound can evaluate the change of length diameter (a) and width diameter (b) of tumor tissue over time and the change of echo of tumor tissue in nude mice;the blood supply and vascular resistance index (RI) value detected by color Doppler ultrasound showed no significant difference; the length diameter, width diameter of tumor measured by ruler, and color Doppler ultrasound showed no significant differences (p > 0.05). Conclusion: Color Doppler ultrasound is of important diagnostic value for ovarian cancer in nude mice. And it is the preferred method to evaluate the growth of intraabdominal implantation tumor in nude mice.