IMR Press / EJGO / Volume 41 / Issue 2 / DOI: 10.31083/j.ejgo.2020.02.5220
Open Access Case Report
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): report of three cases and literature review
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1 Department of Pathology, Shenzhen People's Hospital, Shenzhen, Guangdong Province, China
2 Department of Pathology, Southern Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
3 Department of Pathology, Fourth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
Eur. J. Gynaecol. Oncol. 2020, 41(2), 303–307;
Published: 15 April 2020

Background: Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT), is a rare ovarian tumor with hypercalcaemia mainly affecting young females, but its histogenesis remains largely unknown, which makes it a challenge for effective diagnosis and treatment. This report describes three cases of SCCOHT in young women aging between 23 and 31 years. Material and Methods: All three patients with SCCOHT were subjected to sex hormone and normal blood calcium test, B-ultrasound, and microscopic examination for diagnosis. Expression of low molecular weight Cytokeratin, Vimentin, INI1, WT1, and SMARCA4 were determined by immunohisto-chemistry. Morphological features of cancer cells were observed using electron microscopy, and gene mutation was analyzed by DNA sequencing. Results: All three SCCOHT patients were diagnosed by pathology examination, B-ultrasound, and increased blood calcium level, and underwent surgical resection followed by chemotherapy. Immunohistochemistry showed positive expression of WT-1, CK, INI1, Vimentin, EMA, CD10, and CD56 in tumor tissues of all three cases, but no expression of a-Inhibin, Bcl6, PLAP, Alk, SALL4, SMARCA4, OCT3/4, SF1, Calretinin, MPO, CD20, AFP, CD5, hCG-β, BCL2, ER, and S100. No mutations in FOXL2 gene were detected in these three SCCOHT cases. Two patients died within one year after surgery, and one was lost to follow-up. Conclusion: Three cases of young female SCCOHT patients were reported in this report, featured with poor prognosis even after surgery and chemotherapy.

Small cell carcinoma of the ovary
Figure 1.
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