Cystoid macular edema is a rare adverse event induced by chemotherapy that significantly reduces patient’s quality of life; however, symptoms of visual abnormalities may be indistinguishable from age-related changes. The authors report a case of cystoid macular edema that occurred during chemotherapy for recurrent ovarian cancer. The patient was treated with paclitaxel and carboplatin for six months; however, because of increased tumor size, the authors switched to paclitaxel and bevacizumab. Visual disturbance appeared about one month after the switch. The patient was diagnosed with cystoid macular edema and requested a change in her treatment regimen because of other adverse events, and the macular edema improved within about two months after the change.