IMR Press / EJGO / Volume 40 / Issue 3 / DOI: 10.12892/ejgo4584.2019
Open Access Case Report
Syringoid eccrine carcinoma of the vulva: differential diagnosis, treatment, and follow-up
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1 Gynecological and Obstetric Pathology Unit, Azienda ospedaliero-universitaria Policlinico - Vittorio Emanuele, P.O. S. Bambino, Catania, Italy
2 Gynecology and Obstetrics Unit, Azienda ospedaliera per l'emergenza, Ospedale Cannizzaro, Catania, Italy
3 Medical Oncology Unit, Azienda ospedaliera per l'emergenza, Ospedale Cannizzaro, Catania, Italy
4 Anatomical Pathology Unit, Azienda ospedaliera per l'emergenza, Ospedale Cannizzaro, Catania, Italy
Eur. J. Gynaecol. Oncol. 2019, 40(3), 474–479; https://doi.org/10.12892/ejgo4584.2019
Published: 10 June 2019
Abstract

Purpose of Investigation: The aim of this study is to report an extremely rare case of a syringoid eccrine carcinoma (SEC) of the vulva occurred in a 33-year-old woman who referred to Cannizzaro Hospital Gynecology Unit, and to review other recent cases described in literature speculating on differential diagnosis, prognostic criteria, management, and follow up. Materials and Methods: Accepted criteria on Haematoxylin and Eosin (H&E) sections were used to make the diagnosis. Two pathologists evaluated formalin-fixed tissue sections independently, reaching the same conclusions. Fourteen manuscripts regarding various locations of syringoid eccrine carcinoma were reviewed. Results: Typical features are cells tadpole morphology and perineural and lymphovascular invasion. No standard of care has been established for the treatment of eccrine carcinoma. Wide surgical excision has been often effective. Conclusion: SEC should be taken into consideration in vulvar cancer differential diagnosis. A frequent follow up is essential to detect early recurrence or distant metastases.

Keywords
Syringoid eccrine carcinoma
Adnexal tumors
Sweat gland carcinomas
Syringoma-like tadpole morphology
Perineural invasion
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