IMR Press / EJGO / Volume 40 / Issue 1 / DOI: 10.12892/ejgo4588.2019
Open Access Original Research
Diffusion magnetic resonance in cervical carcinoma: the role of apparent diffusion coefficient in the evaluation of treatment response
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1 Radiology Unit, Sapienza University of Rome, Sant’Andrea Hospital; Rome, Italy
2 Radiotherapy Unit, Sapienza University of Rome, Sant’Andrea Hospital; Rome, Italy
Eur. J. Gynaecol. Oncol. 2019, 40(1), 91–96; https://doi.org/10.12892/ejgo4588.2019
Published: 10 February 2019
Abstract

Purpose: The aim of the study was to determinate the role of apparent diffusion coefficient (ADC) in order to find cut-off values in the evaluation of treatment response. Materials and Methods: A retrospective study was undertaken on MRIs of three groups of patients: 17 with histologically proven cervical carcinoma (group 1), 16 with complete regression after chemo-radiotherapy (group 2), and 46 without pathology (group 3). Three non-overlapping ROIs were manually drawn through neoplastic tissue and normal cervical areas,. regions of interest (ROIs) median values were calculated. Student t-test, ANOVA test, receiver operating characteristic (ROC) curves, and Youden Index were performed. Results: The most important data was obtained by ROC curve and Youden index calculated between free from disease merged group (groups 2+3) and ill patients (group 1): 1.18 x10 -3mm 2/s (94% sensibility, 100% specificity), was the cut-off ADC value. Values below this cut-off could be considered as recurrent pathology with high accuracy. Conclusions: ADC represents a fundamental quantitative tool in follow-up of chemo-radiant treatment response in advanced cervical carcinoma.

Keywords
ADC mapping
Chemoradiation
Diffusion weighted magnetic resonance
Quantitative study
Residual cervical carcinoma
Figures
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