IMR Press / EJGO / Volume 39 / Issue 6 / DOI: 10.12892/ejgo4391.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
"See and treat" LEEP biopsy for cervical intraepithelial neoplasia grade 2/3
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1 Department of Obstetrics and Gynecology, Tokushima University Hospital, Tokushima, Japan
Eur. J. Gynaecol. Oncol. 2018, 39(6), 958–962;
Published: 10 December 2018

Purpose of investigation: To evaluate the safety and efficacy of loop electrosurgical excision procedure (LEEP) biopsy using a “seeand- treat” strategy, and compare outcomes after “LEEP biopsy, inpatient LEEP and ablation, and inpatient conization with cervical intraepithelial neoplasia (CIN) grade 2/3. Materials and Methods: The authors performed a retrospective study including 300 women with CIN2/3 who were followed up ≥ 6 months following outpatient LEEP/inpatient LEEP and ablation/inpatient conization. Recurrence, additional treatment for recurrence, pregnancy, and term delivery following treatment were evaluated. Results: During the median follow-up duration of 22 months, recurrences were significantly more common following LEEP biopsy (39%) compared to LEEP and ablation (13%) and conization (16%) and were managed by repeat LEEP. Pregnancy and full-term delivery rates following LEEP biopsy were significantly higher. Conclusion: “See-and-treat” LEEP biopsy was safely performed in the outpatient department. Pregnancy rates and full-term deliveries following LEEP biopsy appear favorable.
Cervical intraepithelial neoplasia
Papanicolaou test
Uterine cervical neoplasms
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