IMR Press / EJGO / Volume 39 / Issue 6 / 10.12892/ejgo4324.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The compliance of cytology and cytology combined with HPV HR test with a histological biopsy result, indicating cervical pathology
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1 Division of Gynecology, Department of Perinatology and Gynecology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
2 Laboratory of Cervical Pathophysiology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
Eur. J. Gynaecol. Oncol. 2018, 39(6), 947–952;
Published: 10 December 2018
Abstract

Aim: The compliance of cytology and cytology combined with HPV HR test with cervical biopsy result, indicating the presence of cervical pathology was studied. Materials and Methods: The study enrolled 1,300 patients of Laboratory of Cervical Pathophysiology of University of Medical Sciences, who have had an abnormal Pap test and / or suspected cervical pathology following the clinical picture. The largest group consisted of 496 patients with cytological diagnosis of low-grade intraepithelial lesions (LSIL) and 388 patients diagnosed with atypical squamous cells of undetermined significance (ASC-US). Women age ranged from 16 to 79. In each of the women, cytological smear was performed, together with the DNA HPV HR (high-risk oncogenic) test and colposcopy with biopsy of suspected cervical changes. Results: After histopathological verification, 461 (35.4%) of abnormal results were obtained. Compliance of cytological diagnosis of ASC-US with abnormal cervical biopsy reached 15.2%, for atypical squamous cells - cannot exclude HSIL (ASC-H) - 40.4%, for LSIL - 42.1%, for high grade intraepithelial lesions (HSIL) - 63.8%, for atypical glandular cells (AGC) - 25.0%, and for suspected cancer – 77.8%, respectively. Considering HPV test result, the results of cytology with abnormal histopathology was by 5.8–25% higher, depending on the diagnosis, then the compliance of the single Pap smear. Conclusions: Cytology combined with molecular test, results in a significant increase in compliance of the cytological diagnosis with histopathological result. This compliance is the lowest for the cytological diagnosis of ASC-US and gradually increases with advancing cytological diagnosis, reaching the highest values when the cancer is suspected. Both cytological smear and HPV DNA HR test, applied separately, have false negative rates.
Keywords
Cytological smear
HPV test
Screening
Cervical cancer
ASC-US atypical squamous cells of undetermined significance
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