IMR Press / EJGO / Volume 39 / Issue 6 / DOI: 10.12892/ejgo4047.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Palbociclib + fulvestrant in a positive hormonal receptors metastatic breast cancer
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1 Oncology Unit Gard Cancer Institute, NÎmes, France
Eur. J. Gynaecol. Oncol. 2018, 39(6), 1032–1033; https://doi.org/10.12892/ejgo4047.2018
Published: 10 December 2018
Abstract

Palbocilcib is a first-in-class drug, that demonstrated in several studies, improvements in progression-free-survival, in combination with endocrine therapy. Palbociclib with fulvestrant improved progression-free survival in hormone receptor-positive, HER2-negative advanced breast cancer. The author reports the case of a 63-year-old metastatic breast cancer patient, positive for hormonal receptors, that had received multiple chemotherapy regimens. She was treated with palbociclib plus fulvestrant. Three months later she obtained partial response. However she also experienced side-effects such as grade IV neutropenia and grade III thrombopenia, that led to palbociclib reduction.
Keywords
Palbociclib
Fulvestrant
Metastases
breast cancer
Positive hormonal receptors
Neutropenia
thrombopenia
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