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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Case Report
The longest period to recurrence of granulosa cell ovarian tumor: 41 years after initial diagnosise
M. Terzic1, 2, 3, *, I. Likic Ladjevic4, 5, N. Ladjevic5, 6, S. Terzic1, J. Dotlic4, 5, N. Arsenovic7, A. S. Laganà8, A. Vereczkey9
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1
Department of Medicine, Nazarbayev University School of Medicine, Astana, Kazakhstan
2
Department of Gynecology, National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan
3
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburg School of Medicine, Pittsburg, Pennsylvania, USA
4
Clinic of Obstetrics and Gynecology, Clinical Centre of Serbia, Belgrade
5
Medical Faculty, University of Belgrade, Belgrade, Serbia
6
Center for Anesthesiology and Resuscitation, Clinical Centre of Serbia, Belgrade, Serbia
7
Department of Cellular Pathology, PathLinks Pathology Services, Lincoln County Hospital, Lincoln, UK
8
Department of Obstetrics and Gynecology “Filippo Del Ponte” Hospital, University of Insubria, Varese, Italy
9
Versys Clinics Budapest Human Reproduction Institute, Budapest, Hungary
Eur. J. Gynaecol. Oncol. 2018, 39(5), 800–802;
https://doi.org/10.12892/ejgo4470.2018
Published: 10 October 2018
Abstract
Granulosa cell tumors (GCTs) are characterized by slow growth, local spread, and late recurrence. The authors report the case unique for both unusually large dimensions of the recurring tumor and the fact that it was confined only to the omentum, where it has recurred 41 years after the initial surgery including salpingo-oophorectomy. This is the longest reported period from initial diagnosis to the recurrence of GCT. This case report is important as it proves that recurrence of GCT is possible even after an extremely long period of time after the initial surgery, due to the nature of this tumor, and the inhibition of apoptosis process.
Keywords
Granulosa cell tumor
Ovary
Omentum
Relapse
Apoptosis