IMR Press / EJGO / Volume 39 / Issue 5 / DOI: 10.12892/ejgo4325.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Correlation of virtual touch tissue imaging quantification with the Nottingham prognostic index and immunohistochemical features in breast invasive carcinoma
Ting Han1, 2, 3Rong Wu2, 3, *Huan Pu2, 3Ming-Hua Yao2, 3Guang Xu2, 3Hui Liu2, 3Li-Hua Xiang2, 3
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1 Department of Clinical Nutrition, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
2 Department of Ultrasound Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
3 Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China
Eur. J. Gynaecol. Oncol. 2018, 39(5), 727–732; https://doi.org/10.12892/ejgo4325.2018
Published: 10 October 2018
Abstract

Objectives: To investigate the correlation of virtual touch tissue imaging quantification (VTIQ) with the Nottingham prognostic index (NPI), and immunohistochemical features in breast invasive ductal carcinoma. Materials and Methods: In all, 134 patients with breast invasive ductal carcinoma confirmed by histopathology were included. All patients underwent conventional ultrasound and VTIQ to record the average shear wave velocity (SWV) as elasticity mean value (Emean) before the operation; then, postoperative clinical pathology, immunohistochemical features, and NPI score were recorded in order to investigate the correlation of Emean with NPI and immunohistochemical features. Results: Univariate analysis showed that the Emean was in positive correlation with NPI, tumor size, axillary lymph node metastasis, lymph node staging, histology grade, HER-2, and ki67 expressions in breast invasive ductal carcinoma, and the correlation coefficients were positive (r = 0.714, 0.308, 0.635, 0.668, 0.590, 0.221, and 0.559) (p < 0.05). It was in negative correlation with estrogen receptor (ER) (r = -0.373) (p > 0.05) and with progesterone receptor (PR) (r = -0.145) (p > 0.05). Multivariate analysis indicated that only NPI and ki67 were independently positively correlated with the Emean (r = 0.928, r = 0.276) (p < 0.05). Conclusions: The biological characteristics of breast carcinoma can affect its elastic tissue structure, which showed significant association with NPI. Moreover, VTIQ can be used to supplement conventional US to judge the prognosis of breast carcinoma.
Keywords
Breast invasive ductal carcinoma
Immunohistochemistry
Nottingham prognostic index
VTIQ
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