IMR Press / EJGO / Volume 39 / Issue 5 / DOI: 10.12892/ejgo4240.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Expression of plasma miR-106a in epithelial ovarian cancer and its diagnostic and prognostic significance
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1 Department of Reproduction, The Children & Women's Healthcare of LaiWu City, LaiWu, Shandong Province, China
2 Department of Obstetrics and Gynecology, The Children & Women's Healthcare of LaiWu City, LaiWu, Shandong Province, China
3 Department of Obstetrics, The Children & Women's Healthcare of LaiWu City, LaiWu, Shandong Province, China
4 Department of reproduction, Peking University People's Hospital, Beijing, China
Eur. J. Gynaecol. Oncol. 2018, 39(5), 769–772; https://doi.org/10.12892/ejgo4240.2018
Published: 10 October 2018
Abstract

Aims: Circulating microRNAs (miRs) have been investigated as promising novel biomarkers for cancer diagnosis and prognosis. The aim of this study was to evaluate the expression level of plasma miR-106a in patients with epithelial ovarian cancer (EOC) and investigate its clinical significance. Materials and Methods: By using qRT-PCR, the authors compared plasma miR-106a expression in 95 EOC patients and 100 healthy volunteers. The association between plasma miR-106a level and clinicopathological factors was also analyzed. Furthermore, they explored whether plasma miR-106a could serve as a useful biomarker for EOC diagnosis and prognosis. Results: Plasma miR-106a was up-regulated in EOC patients compared with healthy controls (p < 0.01). High plasma miR-106a levels were significantly associated with advanced FIGO stage, high CA125 expression, poor cancer differentiation, and shorter overall survival. ROC curve analysis showed that plasma miR-106a was capable of distinguishing EOC from control subjects. Multivariate Cox regression analysis confirmed high plasma miR-106a expression as an independent unfavorable prognostic factor for EOC. Conclusions: Plasma miR-106a was upregulated in EOC patients and might serve as a novel non-invasive diagnostic and prognostic biomarker.
Keywords
miR-106a
biomarker
epithelial ovarian cancer
diagnosis
prognosis
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