IMR Press / EJGO / Volume 39 / Issue 4 / DOI: 10.12892/ejgo4249.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Association of RAPH1 expression with cervical cancer progression and aggressiveness
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1 Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China
2 Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), ministry of Education, Chengdu, Sichuan, China
Eur. J. Gynaecol. Oncol. 2018, 39(4), 645–648; https://doi.org/10.12892/ejgo4249.2018
Published: 10 August 2018
Abstract

Objective: The gene known as Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (RAPH1) play a role in cellular motility and lamelipodial protrusion, raising the possibility that it may contribute to development of cervical carcinoma and aggressive invasion by tumor cells. Materials and Methods: RAPH1 expression was analyzed in 153 cervical tissue samples at the mRNA level using quantitative RT-PCR and at the protein level using immunohistochemistry. Correlations were explored between expression and clinicopathological features of tumors. Results: Levels of RAPH1 mRNA were significantly higher in carcinoma tissues than in precancerous squamous intraepithelial lesions (SIL) or normal tissue (both p < 0.05). The percentage of RAPH1-positive samples increased progressively from normal tissue (10.0%) and low-grade SIL (31.3%) to high-grade SIL (45.8%) and carcinoma tissue (72.3%; Χ2 CMH = 30.0, p < 0.001). RAHP1 expression positively correlated with grade of tumor differentiation (p = 0.04), vascular invasion (p < 0.001), interstitial invasive depth (p < 0.01), and tumor size (p < 0.01). Conclusions: RAPH1 expression is associated with cervical cancer development and aggressive behavior.
Keywords
RAPH1
Cervical cancer
Carcinogenesis
Tumor development
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