IMR Press / EJGO / Volume 39 / Issue 2 / DOI: 10.12892/ejgo4023.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Squamous cell carcinoma antigen elevation in cervical cancer follow-up: the forest hiding the tree
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1 Department of Obstetrics and Gynaecology, Hospital “Arnaud de Villeneuve”, University Hospital Montpellier, Montpellier Cedex 5, France
2 Dermatology Unit, Hospital “Saint Eloi”, University Hospital Montpellier, Montpellier Cedex 5, France
Eur. J. Gynaecol. Oncol. 2018, 39(2), 324–326; https://doi.org/10.12892/ejgo4023.2018
Published: 10 April 2018
Abstract

Background: The measurement of squamous cell carcinoma antigen (SCC) levels is part of usual follow-up in epidermal cancers, such as epidermal cervical cancers of the uterus. Numerous benign and malign diseases and particularly skin disorders can also create an elevation of SCC. Objective: In this article the authors describe benign diseases leading to an SCC elevation, being able to mislead the physician during follow-up of a patient with a history of epidermal carcinoma. Materials and Methods: The authors describe two cases of patients having suffered a cervical cancer being suspected to have a recurrence after finding elevated SCC-levels. Both patients presented a personal history of psoriasis. Results: Thanks to PET-scan, a recurrence could be ruled out. Several skin disorders have been described to induce an elevation of SCC levels, particularly those affecting the skin-barrier, for example psoriasis. A common criterion is a marked erythema, which may allow an increased penetration of SCC into the blood. Conclusion: In case of SCC-elevation in patients followed for a cervical cancer, dermatological disorders such as psoriasis should be excluded.
Keywords
Cervical cancer
Parakeratosis
Psoriasis
SCC
Tumor marker
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