IMR Press / EJGO / Volume 39 / Issue 2 / DOI: 10.12892/ejgo3953.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Diagnostic value of cancer antigen 72-4 for ovarian cancer: a meta-analysis
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1 Department of ICU, the Third Hospital of Hebei Medical University, Shijiazhuang, China
2 Department of Clinical Laboratory, Shengli Oilfield Central Hospital, Dongying, China
3 Department of Clinical Laboratory, Jinan Infectious Disease Hospital, Jinan, China
4 Department of Clinical Laboratory, Yantai Infectious Disease Hospital, Yantai, China
5 Department of Clinical Laboratory, Dezhou People's Hospital, Dezhou, China
† Contributed equally.
Eur. J. Gynaecol. Oncol. 2018, 39(2), 271–276; https://doi.org/10.12892/ejgo3953.2018
Published: 10 April 2018
Abstract

Objective: This meta-analysis was aimed to evaluate the diagnostic value of CA72-4 as a biomarker in diagnosing ovarian cancer (OC). Materials and Methods: Relevant studies were retrieved through searching PubMed and Embase, up to June 2016. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR), as well as corresponding 95% confidence intervals (CIs) were calculated. The summary receiver operating characteristics curve (SROC) was drawn and the area under SROC (AUC) was calculated. Results: A total of 11 relevant literatures with 891 OC cases and 1,623 controls were identified. The overall estimates of CA72-4 are shown as the follows: sensitivity = 0.49 (95% CI: 0.46-0.53), specificity = 0.89 (95% CI: 0.87-0.90, PLR = 4.62, (95% CI: 2.91-7.34), NLR = 0.52 (95% CI: 0.40-0.67), DOR = 9.17 (95% CI = 4.67-18.03), and AUC = 0.8384 ± 0.1106. Subgroup analyses with four studies (in which 3.8 U/mL was used as cutoff value) showed the slightly higher sensitivity (0.60, 95% CI = 0.54-0.65), specificity (0.93, 95% CI = 0.91-0.94,), PLR (8.27, 95% CI = 6.06-11.27), DOR (20.91, 95% CI = 12.43-35.19), AUC (0.8997 ± 0.1265), and lower NLR (0.42, 95% CI = 0.33-0.52), compared with that in overall analyses. Conclusions: CA72-4 is a biomarker for diagnosing OC with high specificity but low sensitivity. The most appropriate cutoff value should be further explored in further studies.
Keywords
Ovarian cancer
Cancer antigen 72-4
Diagnostic marker
Meta-analysis
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