IMR Press / EJGO / Volume 39 / Issue 2 / DOI: 10.12892/ejgo3738.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Interferon-α receptors and activation pathways in lymphocytes and monocytes in the peripheral blood of patients with cervical intraepithelial neoplasia or invasive cancer
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1 Oncology Research Institute (IPON), Federal University of the Triângulo Mineiro (UFTM), Uberaba, Brazil
2 Discipline of Immunology, UFTM, Uberaba, Brazil
3 Discipline of Gynecology and Obstetrics, UFTM, Uberaba, Minas Gerais, Brazil
Eur. J. Gynaecol. Oncol. 2018, 39(2), 236–241; https://doi.org/10.12892/ejgo3738.2018
Published: 10 April 2018
Abstract

Purpose of Investigation: There is substantial literature demonstrating the effects of type I interferons (IFNs) on viral infections. Here, the authors examined STAT1, IRF-7, and IFN receptors (IFNR1 and IFNR2) in patients with cervical intraepithelial neoplasia (CIN I, II, III) or invasive cervical cancer (ICC) and healthy women. Materials and Methods: Flow cytometry was used to monitor total T lymphocytes (CD3+), T helper cells (CD4+), cytotoxic T cells (CD8+), and monocytes (CD14+). Results: In patients, the numbers of CD3+, CD4+, and CD14+ cells that were positive for IFN-α and the intracellular amounts of this cytokine increased in accordance with lesion progression. Patients showed increased numbers of cells expressing IFNR1 and IFNR2. Patients with neoplasia showed increased numbers of cells positive for STAT1 and IRF7 compared to controls. Conclusion: the antiviral response mediated by IFN-α is increased in the peripheral blood T cells of patients with different stages of cervical neoplasia.
Keywords
Cervical cancer
IFN Receptors
Transcriptional factors
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