IMR Press / EJGO / Volume 38 / Issue 6 / DOI: 10.12892/ejgo3750.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Type-specific prevalence of human papillomavirus among women with abnormal cytology in Jordan
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1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Jordan, Amman, Jordan
2 Elite Moms Clinic, Amman, Jordan
3 The First Medical Laboratories, Amman, Jordan
4 Obstetrics and Gynecology Department, Specialty Hospital, Amman, Jordan
5 Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Jordan
Eur. J. Gynaecol. Oncol. 2017, 38(6), 901–904; https://doi.org/10.12892/ejgo3750.2017
Published: 10 December 2017
Abstract

Background: Infection with human papillomavirus (HPV) is the most common sexually transmitted infection in women worldwide. Infection with high-risk HPV (HR-HPV) is the main cause of cervical cancer. However, little is known about its prevalence in the female population in Jordan. The aim of this study was to discover HPV type-specific prevalence in women living in Jordan. Data regarding HPV type-specific prevalence for a particular country are crucial for providing baseline information to estimate the effectiveness of implementing HPV-based cervical cancer prevention. Materials and Methods: Between 2008 and 2014, cervical epithelium samples were collected by conventional Papanicolaou (Pap) smear; all abnormal smears had reflex HPV testing from apparently healthy and nonhealthy women. HPV prevalence and its genotype distribution were examined in these smears. DNA samples were extracted and HPV genotyping was performed. The results were retrospectively analyzed. Results: A total of 209 abnormal Pap smears were identified and reflex HPV testing was performed on these cases; 153 (73.2%) of the tested cases were HPV positive. The mean age of the women included was 38.3 ± 10.2 (range: 20-70) years and the mean age of HPV-positive women was 38.5 ± 10.3 (range: 21-70) years. There was a significant increase in the incidence of HPV infection over the study period. HPV 6 and 11 infections were very common in the HPV positive women; 38.6% and 47%, respectively. HPV 16 was the single most common (57.5%) HPV infection detected. HPV 30’s (31, 33, 34, 35, and 39) as a group were the most common HPV infections recorded at 59.5%. HPV 50’s (51, 52, 53, 56, 58, and 59) were detected in 56.9% of the cases. HPV type 68 was recorded in one case (0.6%). Of notice, the vast majority of cases had co-infection of multiple genotypes (89%) and only 11% were single genotype infection. Conclusion: The results of the study showed a relatively high prevalence (73.2%) of HPV infection and a higher incidence of co-infection with multiple high risk genotypes (89%) in comparison with other studies from the present region. This study suggests that there is sufficient evidence to warrant further population-based studies and further interventions. HPV vaccination should be considered for Jordanian girls as a preventative measure.
Keywords
HPV
Pap smear
Cervical cancer
Vaccination
Jordan
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