IMR Press / EJGO / Volume 38 / Issue 5 / DOI: 10.12892/ejgo3800.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Clinicopathological features of two cases of uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) and a comprehensive review of literature
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1 Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, L'Hôtel-Dieu de Québec, Laval University, Québec City, Québec, Canada
2 Pathology Department, Centre Hospitalier Universitaire de Québec, L'Hôtel-Dieu de Québec, Laval University, Québec City, Québec, Canada
3 Gynecologic Oncology Division, Centre Hospitalier Universitaire de Québec, L'Hôtel-Dieu de Québec, Laval University, Québec City, Québec, Canada
Eur. J. Gynaecol. Oncol. 2017, 38(5), 793–799; https://doi.org/10.12892/ejgo3800.2017
Published: 10 October 2017
Abstract

Purpose: UTROSCTs are rare neoplasms of the uterine corpus. The authors report the clinicopathological characteristics of two cases of UTROSCTs and review the literature on these tumors. Materials and Methods: Medical records of two patients treated for an UTROSCT were analysed. A comprehensive review of literature was also performed. Results: Case 1:A 49-year old patient underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO) for a suspected leiomyoma. The uterus contained leiomyomas and a 1.8-cm nodule diagnosed as an UTROSCT. Immunohistochemical analysis showed positivity for sex-cord and smooth muscle markers. Case 2: A 43-year-old patient underwent TAH-BSO for a uterine tumor adherent to the sigmoid serosa and pelvic peritoneum. Debulking surgery allowed complete cytoreduction. The pathologic analysis was compatible with UTROSCT. Cells stained for sex-cord and epithelial markers. Patient received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin. Forty months after surgery, a three-cm UTROSCT lesion in the posterior cul-de-sac was surgically removed. Review of Literature: A review of the literature identified 85 cases of UTROSCTs. Hysterectomy is the gold standard therapy. More conservative surgery is an option for selected patients of childbearing age who wish to maintain their fertility potential. Recurrence or metastases are mainly addressed surgically. Conclusion: Due to the scarcity of published cases, there is little definite knowledge about UTROSCTs. UTROSCTs are of low malignant potential, thus long term follow-up is recommended.
Keywords
UTROSCT
Uterine tumors resembling ovarian sex-cord tumor
Uterine tumors
Sex cord-like elements
Chemotherapy
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