IMR Press / EJGO / Volume 38 / Issue 4 / DOI: 10.12892/ejgo3504.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Association between air pollution and female breast cancer: a meta-analysis
Y.Y. Yi1, 2, 3Y.B. Ling1, 2, 3, *X.F. Huang1, 2, 3
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1 Nanjing University of Posts and Telecommunications, Nanjing, China
2 Nanjing Normal University of Special Education, Nanjing, China
3 Affiliated Hospital of Nanjing University of TCM, Nanjing, China
Eur. J. Gynaecol. Oncol. 2017, 38(4), 578–583; https://doi.org/10.12892/ejgo3504.2017
Published: 10 August 2017
Abstract

Objective: To explore whether there is association between air pollution and female breast cancer by conducting a meta-analysis. Materials and Methods: Publications addressing the association between air pollution and female breast cancer risk were selected from PubMed, Medline-Ebsco, Web of Science, Google Scholar, CNKI, and other related research databases. Data were extracted from studies by two independent reviewers. The meta-analysis was performed by R 3.2.0 software, and odds ratio (OR) with a 95%-confidence interval (CI) were calculated. Results: Finally, nine case-control studies were retrieved with a total of independent 43 control groups. Significant association was identified between air pollution and female breast cancer (OR = 1.13, 95% CI: 1.07-1.20, p < 0.0001). Meanwhile, according to the nationality of the study population, stratified analysis found that people in America association between air pollution and breast cancer was statistically significant (OR = 1.13, 95% CI: 1.07-1.20, p < 0.0001); In European populations, the association between air pollution and breast cancer in women was not statistically significant (OR = 0.67, 95% CI: 0.36-1.24, p = 0.2030). In Asian populations, the association between air pollution and breast cancer was statistically significant (OR = 1.71, 95% CI: 1.06-2.76, p = 0.0279). Menopause stratified analysis showed that premenopausal women and the association between air pollution and breast cancer was statistically significant (OR = 1.23, 95% CI: 1.09-1.40, p = 0.0009). For postmenopausal women, association between air pollution and breast cancer was also statistically significant (OR = 1.11, 95% CI: 1.03-1.20, p = 0.0093). Conclusion: The present study confirms that there is association between air pollution and female breast cancer.
Keywords
breast cancer
air pollution
meta-analysis
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