IMR Press / EJGO / Volume 38 / Issue 3 / DOI: 10.12892/ejgo3436.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
A preliminary study for the treatment of cervical colposcopic lesions with the biological compound AV2
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1 Hospital de la Familia, Juarez, Mexico
2 University of Kinshasa, Department of Obstetrics and Gynecology, Kinshasa, Democratic Republic of the Congo
3 University of Antwerp, International Health Unit, Antwerp, Belgium
4 University of Antwerp, Department of Obstetrics and Gynecology, Antwerp, Belgium
Eur. J. Gynaecol. Oncol. 2017, 38(3), 342–345;
Published: 10 June 2017

Objective: To evaluate the efficacy of AntiViral 2 (AV2) in the regression of moderate and severe colposcopic lesions, when compared to placebo. Materials and Methods: Women, aged over 18 years with a colposcopic diagnosis of moderate to severe dysplasia were randomized to receive either two applications of AV2 or placebo within four days. Both examining physician and patients were blinded to the treatment option. Follow-up colposcopy was performed on days 11, 21, and 60. Results: A total of 50 patients were enrolled in this study. There was no statistically significant difference in screening entry criteria between the two groups. The results showed that the application of AV2 yielded a reduction of more than 50% for 21 out of 28 (75%) patients who received the active treatment versus a 0% for the comparable placebo group (p < 0.001). Conclusions: The authors conclude that AV2 can have a place in the treatment of colposcopically-detected cervical lesions. Due to the proven broad spectrum antiviral activity of AV2, a plausible explanation is that the lesions regress due to deactivation of the virus. Further trials with larger numbers and detailed cytology and histology are needed to confirm these results.
Cervical lesion
Human papillomavirus
Essential oil
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