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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Hypoxia induces autophagy in PA-1 ovarian teratoma cells and resistance to growth inhibition and apoptosis by chemotherapeutic agent cis-diamminedichloroplatinum
1 Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China
2 Department of Pediatric Surgery, the 2nd Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
3 Institute of Inflammation & Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Eur. J. Gynaecol. Oncol. 2017, 38(2), 277–281; https://doi.org/10.12892/ejgo3582.2017
Published: 10 April 2017
Pathological hypoxia exists in solid tumors and it creates a microenvironment for tumor cells which has a critical and complicated implication for cancer. Hypoxia can also activate autophagy which plays a dual role in cancer. In this study the authors analyzed the effect of hypoxia, the autophagy inhibitor 3-methyladenine (3-MA), cis-diamminedichloroplatinum (CDDP, cisplatin), and any combination of them on PA-1 cells (a human ovarian cancer cell line) with a series of assays, focusing on autophagy induction, cell growth inhibition, and cell death by CDDP. CDDP caused apoptosis in normoxic PA-1 cells and autophagy upon hypoxia treatment decreased apoptosis induction in hypoxic cells by CDDP, which has implications in cancer chemotherapy resistance.