IMR Press / EJGO / Volume 38 / Issue 2 / DOI: 10.12892/ejgo3382.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Immunohistochemical c-kit expression in uterine serous carcinoma tissue
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1 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, E. Wolfson Medical Center, Holon, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel
2 Department of Pathology, E. Wolfson Medical Center, Holon, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel
Eur. J. Gynaecol. Oncol. 2017, 38(2), 207–208; https://doi.org/10.12892/ejgo3382.2017
Published: 10 April 2017
Abstract

Aim: Uterine serous carcinoma (USC) is an aggressive tumor that represents only 10% of endometrial cancer cases but accounts for a disproportionate number of deaths due to uterine cancer. Advances in the development of specific c-kit receptor-targeted drugs have promoted its potential therapeutic application as a target in tumor-related diseases. The aim of the present study was to evaluate imunohistochemical expression of c-kit in USC tissue in order to assess whether positive cases can be candidates for targeted therapy. Materials and Methods: C-kit expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of confirmed consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Sections of gastrointestinal stromal tumor (GIST) tissue known to contain c-kit served as positive controls. Results: Immunohistochemical c-kit staining was not observed in any of 31 USC tissue samples examined. Intense staining was observed in the sections of GIST tissue. Conclusion: The present results may indicate that primary USC is not a candidate for c-kit targeted therapy.
Keywords
C-kit tissue expression
Uterine serous carcinoma
Targeted therapy
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