IMR Press / EJGO / Volume 38 / Issue 1 / DOI: 10.12892/ejgo3312.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
HE4: really a novel biomarker for ovarian cancer?
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1 Maltepe University, Department of Obstetrics and Gynecology, Istanbul, Turkey
2 Acıbadem University, Department of Biochemistry, Istanbul, Turkey
3 Maltepe University, Department of Anesthesiology and Reanimation, Istanbul, Turkey
Eur. J. Gynaecol. Oncol. 2017, 38(1), 59–64; https://doi.org/10.12892/ejgo3312.2017
Published: 10 February 2017
Abstract

Ovarian cancer forms 4% of all cancers and approximately 23% of all gynecological cancers in women and is responsible for the 47% of deaths related to cancers of the genital tract of women. Tumor markers are the biochemical substances which can be detected in the presence of tumors. Generally they are either the products of tumoral tissues or secreted from the normal cells which are in the interaction with tumoral ones. The present authors attempted to determine the efficacy of the tumor marker CA-125 and HE4 to differentiate the malign cases from the benign adnexal masses. A total of 76 patients with the appropriate criteria were included in the study. They were divided into three groups; healthy control group (n=31), ones with benign masses (n=23), and ones with malign ovarian masses (n=22). In the study, when the cut-off values were accepted as 55I U/ml for CA-125 and 150 pM for HE4 in differentiation of benign and malign groups, the sensitivity was found as 59.09%, specificity 91.3%, PPV 86.67% and NPV 70% LR = +6.8. This combination gives one false positive result to every five positive cases which were detected as high. With the combination of CA-125 and HE4, the value of sensitivity was found decreased as expected, although the value of the specificity increased.
Keywords
HE4
CA-125
Adnexal mass
Ovarian cancer
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