IMR Press / EJGO / Volume 37 / Issue 5 / DOI: 10.12892/ejgo3149.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Growing teratoma syndrome: an unusual evolution of treated ovarian immature teratoma - a case report
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1 Department of General Surgery, Hospital Universitario Araba, Vitoria, Spain
2 Department of Obstetrics and Gynecology, Hospital Universitario Araba, Vitoria, Spain
3 Department of Oncology, Hospital Universitario Araba, Vitoria, Spain
Eur. J. Gynaecol. Oncol. 2016, 37(5), 729–731;
Published: 10 October 2016

Growing teratoma syndrome (GTS) is a rare condition among germ cell tumor (GCT) patients during treatment with systemic chemotherapy. It is characterized by the development of enlarging masses, the normalization of tumor markers, and the presence of only mature teratoma in the pathological specimen. The authors present the unusual case of a 15-year-old girl with an immature teratoma treated with conventional surgery and systemic chemotherapy. On her follow up, although tumor markers returned to normal, there was an enlargement of abdomino-pelvic masses confirmed by a PET/TC study. With the diagnosis of a GTS, the patient underwent a complete cytoreduction. Histologically, all the specimens contained mature teratoma tissue. The patient remains clear with no signs of recurrence with no further treatment. The knowledge and awareness of this syndrome are highlighted in order to prevent further unnecessary chemotherapy and allow an optimal cytoreduction, which seems to be the most effective therapy so far
Growing teratoma syndrome
Germ cell tumors
Immature teratoma
Chemotherapeutic retroconversion
Ovarian neoplasms
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