IMR Press / EJGO / Volume 37 / Issue 5 / DOI: 10.12892/ejgo3112.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
HPV 16 and 18 viral loads are greater in patients with high-grade cervical epithelial lesions
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1 University Center of Biomedical Research, Universidad de Colima, Colima, Mexico
2 School of Medicine, Universidad de Colima, Colima, Mexico
3 Secretaria de Salud Publica de Estado de Colima, Colima, Mexico
4 School of Chemical Sciences, Universidad de Colima, Colima, Mexico
5 Hospital General de Zona 1 IMSS, Colima, Mexico
Eur. J. Gynaecol. Oncol. 2016, 37(5), 644–648;
Published: 10 October 2016

Background: Cervical cancer is the second most common cancer in women worldwide. High-risk infection with HPV type 16 or type 18 is the most important risk factor associated with the development of cervical cancer. Aims: To determine the viral load of HPV-16 and HPV-18 in samples from women with cervical epithelial lesion in the State of Colima, Mexico. Materials and Methods: A crosssectional analytic study was conducted that included 45 samples positive for HPV-16 and 45 samples positive for HPV-18 from patients with cervical cancer or precursor lesion. Real time PCR was employed to determine the number of copies /103 cells. Viral load was determined in the two groups of patients and correlated with tumor grade. Results: THe authors found that the HPV-16 viral load was greater than that of HPV-18 through a Mann-Whitney U analysis, resulting in a p = 0.000; as the malignancy of the cervical lesion progressed, the viral load increased, and HPV-16 showed a moderate positive association with an r = 0.509 and a p = 0.000, whereas HPV-18 showed a weak positive correlation with an r = 0.372 and a p = 0.012. Conclusions: The viral load of HPV-16 was greater than that of HPV-18. The HPV-16 viral load had a moderate positive association in relation to cervical lesion severity, whereas the viral load of HPV-18 had a weak positive correlation with respect to the cervical lesion grade.
Human papillomavirus
Viral load
Cervical lesion
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