IMR Press / EJGO / Volume 37 / Issue 4 / DOI: 10.12892/ejgo3026.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Study of clinical diagnosis of cervical glandular intraepithelial neoplasia
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1 Department of Gynecologic oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
2 Department of pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
Eur. J. Gynaecol. Oncol. 2016, 37(4), 539–542; https://doi.org/10.12892/ejgo3026.2016
Published: 10 August 2016
Abstract

Objective: To preliminarily evaluate the clinical significance of different methods in diagnosis of cervical glandular intraepithelial neoplasia (CGIN). Materials and Methods: Clinical manifestations, ThinPrep cytologic test (TCT), cervical biopsy, and pathological features of 106 patients with CGIN admitted to Beijing Obstetrics and Gynecology Hospital between 2008 and 2011 were retrospectively analyzed. Results: Among 146 cases diagnosed with CGIN, 87 (59.6%) had L-CGIN and 59 (40.4%) H-CGIN. Thirty-seven patients (25.6%) were found to have simple CGIN and 109 (74.6%) had CGIN complicated with cervical intraepithelial neoplasia (CIN). TCT revealed atypical glandular cells (AGC) in 20 patients (13.7%), six of whom had L-CGIN (6.9%) and 14 (23.7%) had H-CGIN with statistical significance between two groups (p < 0.05). TCT detected AGC in 13 cases (35.1%) with simple CGIN and seven with mixed CGIN (6.4%) (P<0.05). Endocervical curettage (ECC) revealed AGC abnormality in ten cases (25.6%). Cervical biopsy under colposcope revealed 32 patients (22.9%) had CGIN, including 15 L-CGIN (18.3%), and 17 H-CGIN (29.3%) with no statistical significance (p > 0.05). Among those diagnosed with CGIN by colposcope-assisted cervical biopsy, 19 (51.4%) had simple CGIN and 13 (11.9%) mixed CGIN (p < 0.05). Conclusion: Preoperative diagnostic rate of simple CGIN was higher than CGIN complicated with CIN
Keywords
Cervical glandular intraepithelial neoplasia
Endocervical glandular dysplsia
Diagnosis
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