IMR Press / EJGO / Volume 37 / Issue 1 / DOI: 10.12892/ejgo2788.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Review
Management of endometrial cancer: issues and controversies
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1 Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
2 Division of Obstetrics and Gynecology, University of Insubria, Varese, Italy
3 Division of Obstetrics and Gynecology, Papa Giovanni XXIII Hospital, Bergamo, Italy
Eur. J. Gynaecol. Oncol. 2016, 37(1), 6–12; https://doi.org/10.12892/ejgo2788.2016
Published: 10 February 2016
Abstract

Although endometrial cancer (EC) is the most common gynecologic cancer in developed countries, several aspects of its management are still controversial. In particular, the need to perform lymphadenectomy represents an important matter of discussion. Because of the discordant results in the literature, it is still not possible to draft any definitive conclusions regarding the therapeutic value of lymph node dissection. The present review discusses the role of lymphadenectomy in the setting of EC, risk factors for lymphatic spread, identification of patients at risk for lymph node dissemination, and the current evidence for adjuvant therapies in patients with positive nodes. Reasons for the difficulty in demonstrating any therapeutic value of pelvic and para-aortic lymphadenectomy are also discussed.
Keywords
Adjuvant therapy
Endometrial cancer
Lymphadenectomy
Staging
Survival
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