IMR Press / EJGO / Volume 37 / Issue 1 / DOI: 10.12892/ejgo2764.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The expression of osteopontin in breast cancer tissue and its relationship with p21ras and CD44V6 expression
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1 Department of Medical Oncology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
2 Department of Pathology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
Eur. J. Gynaecol. Oncol. 2016, 37(1), 41–47; https://doi.org/10.12892/ejgo2764.2016
Published: 10 February 2016
Abstract

Objective: This study aimed to investigate the expression of osteopontin (OPN), p21ras, and CD44V6 in breast cancer tissues, and to analyze the relationships between their expression and a patient's clinicopathological characteristics and five-year survival rate. Materials and Methods: Streptavidin-peroxidase immunohistochemistry was used to detect the expression of OPN, p21ras, and CD44V6 in tissue samples from 96 breast cancer patients, and the multivariate Cox proportional hazards model (mCOX-PHM) was used to analyze the factors that affect prognosis. Results: Among the 96 breast cancer patients studied, positive staining for OPN, CD44V6, and p21ras was observed in 54.2%, 58.3%, and 43.8% of samples, respectively. The expression of OPN and CD44V6 were positively correlated (r = 0.58), and the expression of OPN and p21ras were also positively correlated (r = 0.25). Coexpression OPN, CD44V6, and p21ras was negatively correlated with a patient's five-year survival rate (p < 0.05). Kaplan-Meier analysis indicated that a patient without OPN, CD44V6, or p21ras expression had an improved survival (p < 0.05). Results from the mCOX-PHM analysis indicated that CD44V6 expression, the degree of tumor differentiation, and lymph node metastasis were all independent factors that indicate prognosis. The combined detection of OPN, CD44V6, and p21ras could contribute to a more accurate assessment of the biological behavior of breast cancers, and could help to indicate the prognosis of breast cancer patients.
Keywords
OPN
P21ras
CD44V6
Breast cancer
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