IMR Press / EJGO / Volume 36 / Issue 6 / DOI: 10.12892/ejgo2702.2015

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Decreased microRNA-206 and its function in cervical cancer
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1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shantou University Medical College, Shantou
2 Department of Laboratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou
3 Department of Pathology, Shantou University Medical College, Shantou (China)
Eur. J. Gynaecol. Oncol. 2015, 36(6), 716–721; https://doi.org/10.12892/ejgo2702.2015
Published: 10 December 2015
Abstract

Objective: MicroRNA-206 plays important roles in tumorigenesis and tumor progression of various human malignancies. However, its involvement in cervical cancer has remained unclear. Objective: The aim of this study was to examine the expression patterns and clinical implications of miR-206 in cervical cancer. Materials and Methods: Quantitative RT-PCR was performed to evaluate the expression levels of miR-206 in cervical cancer cell lines and primary tumor tissues. The clinicopathologic significance and the prognostic value of miR-206 expression were further determined. Finally, the effects of miR-206 on HeLa cell proliferation, apoptosis, invasion, and migration were investigated. Results: MiR-206 expression was significantly downregulated in cervical cancer samples when compared with normal adjacent tissues. Low level of miR-206 was associated with advanced FIGO stage (p < 0.001), positive lymph node metastasis (p < 0.001), poor differentiation (p = 0.016), and human papillomavirus infection (p = 0.007). Multivariate Cox regression analysis revealed that decreased miR- 206 expression was an independent unfavorable prognostic factor for overall survival. In addition, transfection of miR-206 mimics in HeLa cells was able to reduce cell proliferation, promote cell apoptosis, and inhibit cell invasion and migration. Conclusions: miR-206 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for molecular therapy of cervical cancer.
Keywords
MicroRNA-206
Cervical cancer
Prognosis
Proliferation
Apoptosis
Invasion
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