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Association of EBV and HPV co-infection with the development of cervical cancer in ethnic Uyghur women
A. Abudoukadeer1, M. Niyazi2, A. Aikula3, M. Kamilijiang3, X. Sulaiman3, A. Mutailipu1, A. Abudula3,4,*
1 Department of Gynecology, First Affiliated Hospital of Xinjiang Medical University, Urumqi
1 Key Research Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi (China)
2 Department of Gynecology, the General Hospital of Xinjiang Uyghur Autonomous Region, Urumqi
3 Department of Biochemistry and Molecular Biology, Xinjiang Medical University, Urumqi
Eur. J. Gynaecol. Oncol. 2015, 36(5), 546–550; https://doi.org/10.12892/ejgo2701.2015
Published: 10 October 2015
Objective: Study on the role of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of cervical cancer. Materials and Methods: We collected 178 cases of cervical tissue specimens of Uyghur women with cervicitis, cervical intraepithelial neoplasia (CIN I, CIN II-III), and cervical squamous cell carcinoma (CSCC). EBV- and HPV-DNA were detected by PCR of tissue DNA. EBV protein expression was checked by immunohistochemistry. Results: HPV-DNA was detectable in 2.5, 12.5, 68.0, and 96.4% of cases of cervicitis, CIN I, CIN II- III, and cervical cancer, respectively. For EBV-DNA, these numbers were 0, 3.1, 28.0, and 69.6%. There was a significant difference between the groups of cervicitis, CIN II-III, and cancer with respect to both HPV and EBV positivity rates (p < 0.05). Further analysis indicated that cervical lesion pathogenesis was not only accompanied by a gradually increasing rate of HPV or EBV-DNA alone, but also by an increasing rate of HPV-EBV dual infection (r = 0.46; p < 0.01). EBV protein expression was positive in 89.7% of EBV-DNA positive cases (34/39) and 6% of EBV-DNA negative cases (1/17). Conclusion: Cervical cancer development and progression may be closely associated with the dual-infection by HPV and EBV.