IMR Press / EJGO / Volume 36 / Issue 4 / DOI: 10.12892/ejgo2672.2015

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Serum human epididymis protein 4 can be a useful tumor marker in the differential diagnosis of adnexal masses during pregnancy: a pilot study
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1 Kahramanmaras Sutcu Imam University School of Medicine Department of Obstetrics and Gynecology, Kahramanmaras
2 KSU School of Medicine Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Kahramanmaras
3 Kahramanmaras Sutcu Imam University School of Medicine Department of Biochemistry, Kahramanmaras
4 Sakarya University School of Medicine Department of Public Health, Sakarya (Turkey)
Eur. J. Gynaecol. Oncol. 2015, 36(4), 406–409;
Published: 10 August 2015

Purpose: The purpose of this study was to evaluate serum concentrations of human epididymis protein 4 (HE4) and cancer antigen 125 (CA 125) in healthy women and their pregnant counterparts to determine the influence of pregnancy on these biomarkers. Materials and Methods: Serum concentrations of CA 125 and HE4 were measured in 27 healthy non-pregnant women and 26 healthy pregnant women in the first and second trimesters. Results: Higher concentration of CA 125 was found in pregnants than in non-pregnant women (p = 0.002). There was no difference in CA 125 concentrations between first and second trimesters (p = 0.13). Serum HE4 concentration was not different in pregnant group compared to non-pregnant women (p = 0.510). Likewise, no difference was found in HE4 levels between the trimesters (p = 0.485). There was a positive correlation between increasing parity and CA 125 (p = 0.023), but not HE4 (p = 1.0). Conclusion: HE4 serum biomarker is unaffected by pregnancy status and may be useful for evaluation of doubtful pelvic masses in pregnancy. Contrarily, increased serum levels of CA 125 could yield increased number of false-positive results.
Cancer antigen 125
Human epididymis protein 4
Tumor markers in pregnancy
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