Purpose of investigation: This study aimed to assess the role of omentectomy in the surgical therapy of endometrial cancer. Materials and Methods: A retrospective study was performed in 98 patients who were pathologically diagnosed with endometrial cancer and had initially undergone surgical therapy at the present institution. This study analyzed the relationship between omental metastasis and clinicopathological factors. Results: Omental metastasis was detected in nine patients (9%). On univariate analysis, significant number of omental metastatic lesions were detected in few cases by positive peritoneal cytology, adnexal metastasis, gross dissemination, and lymphovascular space involvement. On multivariate analysis, adnexal metastasis were a significant risk factor. The sensitivity of the special histological type and the specificity of the macroscopic peritoneal dissemination and adnexal metastasis were all high. Conclusion: Omentectomy plays a significant role in determining the exact surgical staging in cases with non-endometrioid cancer, adnexal metastasis, and macroscopic peritoneal dissemination.