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Prevention, diagnosis and treatment of cervical cancer precursor lesions at the Xingu Indigenous Park, Brazil
E. Ribeiro Pereira1,*, N. M. de Gois Speck2, D. A. Rodrigues1, V. Grisolia de Freitas2, J. C. Lascasas Ribalta2
1 Departments of Preventive Medicine, Federal University of São Paulo City, São Paulo
2 Departments of Gynecology, Federal University of São Paulo City, São Paulo (Brazil)
Eur. J. Gynaecol. Oncol. 2015, 36(4), 376–382; https://doi.org/10.12892/ejgo2649.2015
Published: 10 August 2015
Purpose: To describe the prevention, diagnosis, and treatment of cervical cancer precursor lesions at the Xingu Indigenous Park (PIX) from 2005 to 2006. Materials and Methods: Observational, transversal study. The research sample consisted of 503 sexually active women aged 12 years and older. The research was performed in three stages: screening, colposcopy, and surgical treatment by large loop excision of the transformation zone. Results: The cytopathological screening coverage was of 99.6%. The rate of cytologic atypia was 11.7%. Together, low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous intraepithelial lesions (HSILs) were observed in 4.6% of the women. The cytological examination returned a sensitivity of 54%, specificity of 97%, a positive predictive value of 88%, and a negative predictive value of 83%. In the anatomopathological examinations of biopsies, the rate of HSILs was 30.2%. The sensitivity of the anatomopathological examination of biopsies was 72.2%, the specificity was 100%, the positive predictive value was 100%, and the negative predictive value was 44.4%. Conclusions: Viable strategies for preventing, diagnosing, and treating cervical cancer precursor lesions in women from the PIX include increasing annual coverage of cytopathological examinations, early detection of cervical intraepithelial lesions, and treatment and follow-up of detected cases.
Cervical intraepithelial neoplasia
Cervical neoplasm prevention
South American Native Indians