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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Anti-Hsp20 antibody concentrations inversely correlated with tumor progression in ovarian cancer
Yanhui Zhu1,*, Qingchao Tian2, Naian Qiao3, Yin Cheng4, Haiying Li5
1 Medical Informatics Center, Peking University, Beijing
2 Department of Obstetrics and Gynecology, Jinan third People’s Hospital, Jinan
3 Department of Radiotherapy, Shandong University Qilu Hospital, Jinan
4 Department of Science and Education, Jinan third People’s Hospital, Jinan
5 Division of Ultrasonography, Shandong University Qilu Hospital, Jinan, (China)
Eur. J. Gynaecol. Oncol. 2015, 36(4), 394–396; https://doi.org/10.12892/ejgo2623.2015
Published: 10 August 2015
Purpose: To investigate the serum concentrations of anti-heat shock protein 20 (anti-Hsp20) antibodies in women with ovarian cancer at different clinical stages, and the relationship between these concentrations and tumor progression. Materials and Methods: Blood samples were obtained from 72 patients undergoing surgery for ovarian cancer, 21 women with ovarian carcinoid, and 42 healthy women. Anti-Hsp20 antibody concentrations were determined by enzyme-linked immunosorbent assay. Results: Mean anti- Hsp20 antibody concentrations were significantly lower in patients with ovarian cancer than in the control group. The anti-Hsp20 antibody concentrations were negatively correlated with ovarian cancer malignancy. Conclusions: The present findings suggest that anti-Hsp20 antibodies may play a protective role against ovarian cancer progression, and that anti-Hsp20 antibodies may be a new index for the early diagnosis and treatment of ovarian cancer.
Heat shock protein