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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Overexpression of PI3K-p110α in the progression of uterine cervical neoplasia and its correlation with pAkt and DJ-1
S. K. Choi1, Y. O. Hong1, W. M. Lee1, E. K. Kim1, J. E. Joo1, D. W. Kim2, H. Lee1,*
1 Department of Pathology, Eulji Medical Center, Eulji University School of Medicine, Seoul (Korea)
2 Department of Obstetrics and Gynecology, Eulji Medical Center, Eulji University School of Medicine, Seoul (Korea)
Eur. J. Gynaecol. Oncol. 2015, 36(4), 389–393; https://doi.org/10.12892/ejgo2591.2015
Published: 10 August 2015
Objective: To investigate the expression of PI3K-p110α, pAkt, PTEN, the signaling molecules from PI3K/Akt signaling pathway, DJ- 1, an oncoprotein and HSP90α, a molecular chaperone, and their correlation in uterine cervical neoplasia, in order to elucidate their role in cervical carcinogenesis. Materials and Methods: Using immunohistochemistry, the authors analyzed the expression of PI3K-p110α, pAkt, PTEN, DJ-1 and HSP90α, and their correlation in ten normal tissues, cervical intraepithelial neoplasia (CIN) including 30 CIN1 and 31 CIN3, and 33 cases of invasive squamous cell carcinoma (SCC). Results: The expression of all proteins significantly increased in CIN3 compared to CIN1, and only the expression of PI3K-p110α significantly increased in invasive SCC compared to CIN3. There was a significant positive correlation between the expression of PI3K-p110α and DJ-1, as well as PI3K-p110α and pAkt in CIN3 and invasive SCC. Conclusion: Overexpression of PI3K-p110α is associated with progression of uterine cervical neoplasia, and the expression of pAkt and DJ-1 is positively correlated with PI3K-p110α expression in this process.
Cervical intraepithelial neoplasia
Squamous cell carcinoma