IMR Press / EJGO / Volume 36 / Issue 3 / DOI: 10.12892/ejgo2630.2015

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Identification of potential targets for ovarian cancer treatment by systematic bioinformatics analysis
Q. Ye1,†L. Lei1,†A. X. Aili1,*
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1 Department of Obstetrics and Gynecology, Shanghai East Hospital, Tongji University, Shanghai (China)
These authors contributed equally.
Eur. J. Gynaecol. Oncol. 2015, 36(3), 283–289;
Published: 10 June 2015

Purpose of investigation: To provide a systematic overview to understand the mechanism of ovarian cancer. Materials and Methods: Data of GSE14407 downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified. Gene ontology and pathway enrichment analysis were performed by Database for Annotation, Visualization and Integrated Discovery (DAVID). Furthermore, the authors constructed the protein-protein interaction (PPI) network and co-expression networks by Cytoscape. Results: A total 1,442 genes were identified to be differentially expressed. Regulatory effects of DEGs mainly focused on cell cycle, transcription regulation, and cellular protein metabolic process. Significant pathways were determined to be p53 signaling pathway, amino sugar, and nucleotide sugar metabolism. The most significant transcription factor was aryl hydrocarbon receptor nucleartranslocator (ARNT). Abnormal spindle-like microcephaly-associated protein (ASPM), Aurora kinase (AURKA), Cyclin-A2 (CCNA2), G2/mitotic-specific cyclin-B1, (CCNB1), and Cyclin-dependent kinase 1 (CDK1) were significant nodes in PPI network. Conclusion: The significant genes and pathways show potential targets for the treatment of ovarian cancer.
Ovarian cancer
Protein-protein interaction
Co-expression network
Gene ontology analysis
Pathway enrichment analysis
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