Announcements
European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
The prognostic significance of pretreatment [18F]FDG-PET/CT imaging in patients with uterine cervical cancer: preliminary results
Show Less
1
Department of Obstetrics and Gynecology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul
2
Department of Radiation Oncology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul
3
Department of Nuclear Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul
4
Department of Pathology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul (Korea)
Eur. J. Gynaecol. Oncol. 2015, 36(1), 30–35;
https://doi.org/10.12892/ejgo2549.2015
Published: 10 February 2015
Abstract
Purpose of Investigation: To evaluate the prognostic significance of positron emission tomography/computed tomography (PET/CT) in patients diagnosed with cervical cancer. Materials and Methods: Patients with cervical cancer in FIGO Stages IB1 to IVB were imaged with PET/CT prior to treatment during one of the staging work-ups. The patients were observed for a median of 31.4 months (range, six to 89 months) after the initial treatment. The standardized uptake value (SUV) max of the primary cervical tumor mass was compared with the prognostic factors. Results: A total of 81 patients who were primarily treated with radical hysterectomy (RH, n=45) or concurrent chemoradiation (CCRT, n=36) were analyzed. Multivariate analysis indicated that larger tumor size (> 4 cm, OR 8.694, 95% CI, 1.638-46.146), deep stromal invasion (≥ 1 cm, OR 7.249, 95% CI, 1.141-46.039) by the primary tumor, and pathologically confirmed pelvic lymph node involvement (positive, OR 14.586, 95% CI, 2.072-102.674) were significantly associated with recurrence after treatment. However, pretreatment SUVmax was not a significant independent predictor of disease recurrence (OR 1.058, 95% CI, 0.255-4.398). Conclusion: [18F]Fluorodeoxyglucose (FDG) uptake by the primary tumor showed a significant association with several risk factors that have been identified as treatment predictors. However, a high pretreatment SUVmax was not predictive of recurrence in uterine cervical cancer patients.
Keywords
FDG-PET/CT
SUVmax
Uterine cervical cancer
Recurrence
Prognostic factor