IMR Press / EJGO / Volume 35 / Issue 6 / DOI: 10.12892/ejgo25362014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Uterine endometrioid carcinoma with focal area of choriocarcinomatous differentiation: case report
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1 Department of Life, Health & Environmental Sciences, University of L’Aquila, L’Aquila (Italy)
Eur. J. Gynaecol. Oncol. 2014, 35(6), 731–733;
Published: 10 December 2014

Purpose of Investigation: An endometrioid carcinoma coexisting with choriocarcinomatous differentiation is an uncommon event with an aggressive clinical course and a poor prognosis. Materials and Methods: The authors describe an endometrioid carcinoma of the endometriumprovided with a focus of choriocarcinoma-like cells in a 50-year-old menstruated woman with a history of abnormal uterine bleeding. A total bilateral hystero-annessectomy was performed. Results: Histopathologic study showed endometrioid adenocarcinoma limited to the endometrium with a single microinvasive (< one mm) choriocarcinomatous focus. Immunohistochemistry established intense reactivity of tumor cells for CK 7 and AE1/AE3, for beta-human chorionic gonadotropin (β-hCG), and for HER2 confirming the diagnosis. During the clinical course and follow-up, serum levels of β-hCG were always negative. Up to date the patient is still alive with no evidence of disease. Conclusion: Even if endometrioid carcinoma with choriocarcinomatous differentiation is considered highly malignant, occasionally it may have a good prognosis, especially when a non-invasive behaviour is detected together with negative serum β-hCG levels.
Endometrioid carcinoma
Trophoblastic tumor
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