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Meigs’ syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma
1 Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul
1 Ulsan University Hospital, Ulsan
2 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine
3 Department of Obstetrics and Gynecology, University of Inje College of Medicine, Haeundae Paik Hospital, Busan (Korea)
Eur. J. Gynaecol. Oncol. 2014, 35(6), 734–737; https://doi.org/10.12892/ejgo25282014
Published: 10 December 2014
Meigs' syndrome is the association of benign ovarian tumor, pleural effusion, and ascites. Meigs’ syndrome with marked elevated CA 125 is a rare clinical entity and only 42 cases have been reported. Although there is difficulty in discerning the diagnosis of Meigs’ syndrome from that of an ovarian malignancy, it should be considered in the differential diagnosis in postmenopausal patients with an ovarian mass, hydrothorax, ascites, and elevated CA 125. In this report, the authors present the case of a 52-year-old postmenopausal woman with ovarian fibrothecoma, pleural effusion, ascites, and elevated CA 125 (319.2 IU/ml). Exploratory laparotomy with total hysterectomy and bilateral salpingo-oophorectomy was performed, and the pathologic diagnosis was ovarian fibrothecoma. After the surgery, the pleural effusion disappeared spontaneously and the CA 125 became normal. The authors also summarized other cases of Meigs’ syndrome with elevated CA 125, and reviewed the mechanism of elevation of CA 125, ascites, and pleural effusion.