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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
The role of levonorgestrel-releasing intrauterine system for endometrial protection in women with breast cancer taking tamoxifen
Qingquan Shi1, Jinhong Li2, Ming Li1, Jing Wu1, Qiang Yao1, Aiyun Xing1,*
1 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu
2 Department of Urology, West China Hospital, Sichuan University, Chengdu (China)
Eur. J. Gynaecol. Oncol. 2014, 35(5), 492–498; https://doi.org/10.12892/ejgo25822014
Published: 10 October 2014
Purpose of Investigation: To review the evidence concerning the efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in preventing endometrial pathology in women treated with tamoxifen. Materials and Methods: Randomized controlled trials (RCTs) of women with breast cancer on tamoxifen that compared endometrial surveillance or placebo alone vs. the LNG-IUS were reviewed. The eligible trials were identified from the following electronic databases: Cochrane CENTRAL, Medline, and EMBASE. The authors extracted data on all reported outcomes and conducted meta-analyses on the endometrial polyps, endometrial hyperplasia, proliferative endometrium, and endometrium thickness. Results: According to the subgroup analysis, a significant reduction of endometrial polyps was obtained (OR=0.22, 95% CI 0.13-0.37, p < 0.00001). The use of LNG-IUS reduced the incidence of endometrial hyperplasia (OR=0.13, 95% CI 0.03-0.58, p = 0.007) Increased abnormal vaginal bleeding for LNG-IUS users may be an adverse aspect of LNG-IUS. Conclusion: This meta-analysis confirms that endometrial hyperplasia is also reduced as well as endometrial polyp formation reduced after long-term follow-up.
Levonorgestrel-releasing intrauterine system (LNG-IUS)