IMR Press / EJGO / Volume 35 / Issue 5 / DOI: 10.12892/ejgo25602014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer
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1 Department of Radiotherapy, Shandong University Qilu Hospital, Jinan
2 Medical Informatics Center, Peking University, Beijing
3 Division of Ultrasonography, Shandong University Qilu Hospital, Jinan
4 Division of Ultrasonography, Shandong Provincial Hospital, Jinan (China)
These authors contributed equally.
Eur. J. Gynaecol. Oncol. 2014, 35(5), 576–579; https://doi.org/10.12892/ejgo25602014
Published: 10 October 2014
Abstract

Objective: To investigate a possible correlation between expression levels of heat shock protein 20 (HSP20) and tumor progression in patients with ovarian cancer. Materials and Methods: The study included 34 patients with ovarian cancer who were to undergo surgery, seven patients with ovarian carcinoid tumors, and five patients with normal ovaries as a control group. Ovarian tissues were obtained from patients by surgical resection and then analyzed by western blot. Results: Expression levels of HSP20 were inversely correlated with the grade of malignancy. Conclusion: The present findings suggest that HSP20 may play a protective role against the progression of ovarian cancer. Thus, HSP20 may represent a new target for the prediction and treatment of ovarian cancer.
Keywords
HSP20
Ovarian cancer
Tumor progression
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