IMR Press / EJGO / Volume 35 / Issue 5 / DOI: 10.12892/ejgo25192014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Breast conserving surgery in multicentric breast cancer, preliminary data of our experience
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1 TEI Technological University of Athens, Athens
2 Rea and Leto Hospital, Athens
3 University of Ioannina, Department Obstetrics & Gynaecology, Ioannina
4 University of Montpellier-Nimes, Department of Obstetrics & Gynecology & Biostatistics, Montpellier-Nimes (France)
5 University of Athens, Attikon Hospital, 3rd Department of Obstetrics & Gynaecology, Athens (Greece)
These authors contributed equally.
Eur. J. Gynaecol. Oncol. 2014, 35(5), 530–534;
Published: 10 October 2014

Introduction: It is widely supported that multicentric disease of the breast (MCDB) is a contraindication of breast conservative surgery (BCS). Materials and Methods: This is a multicentric study (two breast cancer units from Greece, one from France) involving patients with at least two primary tumors in separate quadrants of the breast and no diffuse suspicious microcalcifications on mammography. Sixty-one patients were included in the study, but 49 were followed up to the end. Patients were randomly assigned in total mastectomy (TM) and BCS groups. End point of the study was disease-free survival rates three and five years after initial operation. Results: Three years after BCS, local recurrence (LR) was observed in two patients (7%) and one after five years (total recurrence rate:11%). A TM was performed in these patients, and in two there was no LR or distant metastasis (DM) five years after. The third patient was disease free two-years later. Three years after TM, eight patients (36.4%) had DM and 14 (63.6%) did not (p = 0.004). Five years after TM, eight patients (36.4%) had DM and 14 patients (63.6%) di not (p = 0.03). Conclusion: The results showed that conservative surgery was an alternative surgical option in multicentric breast cancer with good results regarding disease-free survival and recurrence.
Multicentric breast cancer
Conserving surgery
Total mastectomy
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