IMR Press / EJGO / Volume 35 / Issue 4 / DOI: 10.12892/ejgo26802014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Predictors of malignancy in endometrial polyps: a multi-institutional cohort study
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1 Department of Women’s and Children’s Health, Obstetrics and Gynecology Clinic, University of Padua, Padua
2 Woman's Health Sciences Department, Università Politecnica delle Marche, Ancona (Italy)
Eur. J. Gynaecol. Oncol. 2014, 35(4), 382–386;
Published: 10 August 2014

Purpose of investigation: The risk of endometrial cancer in women with endometrial polyps (EPs) has been reported to vary between 0.3% and 4.8%. There is a lack of data about the management of asymptomatic women with incidental diagnosis of EPs. In the present study the authors correlated demographic and clinical characteristics with histopathological features of the EPs hysteroscopically removed. Materials and Methods: An observational multi-institutional cohort study was conducted from February 2010 to December 2012 to identify all the premenopausal and postmenopausal women consecutively undergoing hysteroscopic polypectomy. The data of women were reviewed and clinical features were related to histopathologic results. Results: The patients recruited were 813. The mean age was 52.5 years (range 22-87). The results showed a correlation between older age, high body mass index (BMI) and obesity, postmenopausal state, abnormal uterine bleeding (AUB), hypertension, and risk of malignant EPs. On multivariable analysis, the correlation remained only for age (OR 1.08, 95% CI 1.03 - 1.14) and AUB (OR 3.53, 95% CI 1.87 - 6.65). Conclusion: Older patients in postmenopausal status with AUB, a high BMI, and hypertension are at higher risk for premalignant and malignant polyps. In these patients a surgical approach should be used, consisting in hysteroscopical removing of the polyp.
Endometrial polyps
Body mass index
Endometrial cancer
Hysteroscopic polypectomy
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