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Cite this article
Uterine endometrial carcinoma with trophoblastic differentiation: a case report with literature review
1 Department of Obstetrics and Gynecology
2 Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo (Japan)
Eur. J. Gynaecol. Oncol. 2014, 35(4), 461–464;
Published: 10 August 2014
Choriocarcinoma is categorized as either gestational or nongestational depending on its origin. Nongestational choriocarcinoma originated in the trophoblastic differentiation is a rare but an aggressive tumor. This article reports a nongestational case of a uterine endometrial carcinoma with trophoblastic differentiation. A 54-year-old woman with a history of atypical genital bleeding that underwent semi-radical hysterectomy, bilateral salpingo-oophrectomy, and pelvic lymph nodes dissection. Pathological investigation showed that the tumor had endometrioid adenocarcinoma and choriocarcinomatous components. Although a series of multimodality treatments including craniotomy were performed, she died of aggressive lung and brain metastases one year after the primary surgery.