IMR Press / EJGO / Volume 35 / Issue 4 / DOI: 10.12892/ejgo24612014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Review
The importance of alpha/beta (!/") interferon receptors and signaling pathways for the treatment of cervical intraepithelial neoplasias
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1 Oncology Research Institute, IPON, Federal University of Triangulo Mineiro (UFTM), Uberaba, MG
1 Uberaba, MG (Brazil)
2 Discipline of Immunology, Oncology Research Institute (IPON), Federal University of Triângulo Mineiro (UFTM), Uberaba, MG
3 Discipline of Gynecology and Obstetrics, Oncology Research Institute (IPON), Federal University of Triângulo Mineiro (UFTM)
Eur. J. Gynaecol. Oncol. 2014, 35(4), 368–372; https://doi.org/10.12892/ejgo24612014
Published: 10 August 2014
Abstract

Introduction: Immunotherapies have been effective in treating various forms of cancer, including cervical intraepithelial neoplasias (CINs) predominantly caused by human papilloma virus (HPV). Development: To establish persistent infections in stratified epithelia, HPV induces proliferative lesions. Viral gene products are able to change gene expression and cellular proteins. Interferons (IFNs) are inducible glycoproteins that have immunomodulatory, antiviral, antiproliferative, and antiangiogenic effects. In particular, interferonalpha (IFN-!) has been shown to inhibit the development and progression of cervical cancer. In this review, actions of interferons !/beta (!/"), including their receptors and signaling pathways, are described, as well as their clinical importance in the immune response against cervical lesions. Conclusion: The interaction of IFN-!/" with its receptor results in a series of phosphorylation events. These mechanisms can be ineffective in IFN response, then it can also compromise the therapeutic effects of immunotherapy.
Keywords
Type I Interferons
Interferon receptors
Cervical neoplasia
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