IMR Press / EJGO / Volume 35 / Issue 3 / DOI: 10.12892/ejgo24392014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Importance of platinum-free interval in second-line chemotherapy for advanced or recurrent endometrial cancer
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1 Department of Gynecology Cancer Institute Hospital, Tokyo (Japan)
Eur. J. Gynaecol. Oncol. 2014, 35(3), 224–229; https://doi.org/10.12892/ejgo24392014
Published: 10 June 2014
Abstract

Purpose: To investigate the effectiveness of platinum-based combination chemotherapy as second-line chemotherapy for patients with advanced or recurrent endometrial cancer treated initially by platinum-based combination chemotherapy. Materials and Methods: Subjects were patients who had received platinum-based combination chemotherapy as second-line chemotherapy: 56 patients with recurrent disease who had previously received postoperative adjuvant platinum-based combination chemotherapy (Category 1) and 21 patients who had received first-line chemotherapy but not adjuvant chemotherapy for advanced or recurrent disease (Category 2). Patients’ records were searched for the response to second-line chemotherapy and survival, particularly in relation to the platinum-free interval (PFI). Results: A PFI over 12 months was a predictor of response (64.7%) and overall survival time (23 months) in Category 1 patients.A PFI of less than three months was a negative predictor of response (0%) and overall survival (nine months) in Category 2 patients. Conclusion: Platinum-based combination chemotherapy appears to be effective as second-line chemotherapy for endometrial cancer if the PFI is sufficiently long.
Keywords
Second-line chemotherapy
Advanced and recurrent endometrial cancer
Platinum-free interval
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