IMR Press / EJGO / Volume 35 / Issue 2 / DOI: 10.12892/ejgo23952014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Malignant mixed Müllerian tumor with small cell neuroendocrine differentiation: a case report and review of the literature
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1 Akdeniz University Hospital, Department of Gynecological Oncologic Surgery, Antalya
2 Department of Medical Pathology, Antalya (Turkey)
Eur. J. Gynaecol. Oncol. 2014, 35(2), 180–184;
Published: 10 April 2014

Introduction: Small cell neuroendocrine differentiation (NE) in malignant mixed Mullerian tumors (MMMTs) is a rare and unusual occurrence with very few previously reported cases. There is no consensus regarding its diagnosis, classification, and optimal treatment options. Case: The authors report a patient with endometrial MMMT and NE differentiation who initially received comprehensive surgery followed by adjuvant chemotherapy containing cisplatin and etoposide. She further underwent metastasectomy and received carboplatin and paclitaxel for the relapse. She is still alive 12 months after the diagnosis. The authors performed a review of literature in order to characterize the clinical phenotype. These patients have a very aggressive disease. Median life expectancy seems to be less than a year. Conclusions: It is reasonable to perform comprehensive staging surgery followed by adjuvant chemotherapy irrespective to stage of the disease.
Malignant mixed Müllerian tumor
Small cell neuroendocrine differentiation
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