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Cite this article
Expression of p53 protein in the endometrial polyp in postmenopausal women
L. C de Albuquerque Neto1,*, J. M. Soares Jr2, M. G. Giusa-Chiferi1, W. J. Gonçalves Gonçalves1, E. C. Baracat2
1 Department of Gynecology, Federal University of São Paulo Escola Paulista de Medicina, São Paulo
2 Department of Obstetrics and Gynecology, Facultade de Medicina da Universidade de São Paulo, São Paulo (Brazil)
Eur. J. Gynaecol. Oncol. 2013, 34(6), 509–512;
Published: 10 December 2013
Objective: To evaluate p53 protein expression in the endometrial polyp and compare with adenocarcinoma and atrophic endometrium of postmenopausal women. Materials and Methods: Ninety-eight postmenopausal women were included in this study and divided into three groups related to histopathologic diagnosis: Group A - endometrial adenocarcinoma (n = 40), Group B – endometrial polyp (n = 38), and Group C – endometrial atrophy (n = 20). The length of this study was from 1990 to 2004. The endometrial samples were collected from hysteroscopic biopsy or surgery then processed for histopathologic routine. One thousand cells of each histological sectionwere evaluated for immunohistochemical analysis using p53 antibodies. The ANOVA test wasperformed for the statistical analysis. Results: The expression of p53 in adenocarcinoma samples was the highest. The expression of polyp was positive when associated to hyperplasia without atypia. All samples of atrophic endometrial were negative. Conclusions: The present data suggested that presence of hyperplasia in the endometrial polyp is factor to increase the expression of p53.