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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
A comparison of outcomes between concurrent chemoradiotherapy and radiotherapy alone in cancer of the uterine cervix: a single institutional experience
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1
Departments of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu
2
Departments of Obstetrics and Gynecology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu (Korea)
Eur. J. Gynaecol. Oncol. 2013, 34(5), 402–408;
Published: 10 October 2013
Abstract
Purpose: To compare failure patterns and evaluate prognostic factors related to survival rates after concurrent chemoradiotherapy (CCRT) or radiotherapy (RT) alone in cervical cancer. Materials and Methods: From January 1996 to December 2006, 218 patients with cervical cancer (FIGO Stage IB2 - III) treated with CCRT or RT alone as primary treatments were included, retrospectively. One-hundred eight patients were treated with CCRT and 110 with RT alone. Results: There was no significant difference in failure patterns between the treatment groups, but distant metastasis was the predominant pattern in both groups. The frequent metastatic sites were supraclavicular lymph node, lung, and brain. Treatment group, diabetes, and FIGO Stage werefound to be significant for overall survival(OS) and disease-free survival (DFS), and initial hemoglobin level for DFS. Conclusion: Distant metastasis is the predominant failure pattern and diabetes is one of the independent prognostic factors to survival rates in this study.
Keywords
Uterine cervical neoplasm
Concurrent chemoradiotherapy
Radiotherapy
Treatment outcome
Prognosis