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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Uterine tumor resembling ovarian sex cord tumor. Case report and review of literature
A. Stefanovic1,3,*, K. Jeremic1,3, S. Kadija1,3, M. Mitrovic1, D. Filimonovic2,3, S. Jankovic-Raznatovic2,3, J. Tavčar Tavčar1
1 Clinic of Obstetrics and Gynecology, Clinical Centre of Serbia
2 Clinic of Obstetrics and Gynecology “Narodni Front”
3 Medical School University of Belgrade, Belgrade (Serbia)
Eur. J. Gynaecol. Oncol. 2013, 34(3), 275–277;
Published: 10 June 2013
A uterine tumor resembling an ovarian sex cord tumor (UTROSCT) shows a poly phenotypic immunophenotype with coexpression of epithelial, myoid, and sex cord markers, as well as hormone receptors. The authors present a case of a 59-year-old multiparous woman admitted to the Institute of Gynecology and Obstetrics Clinical Centre of Serbia in January 2010 due to prolonged vaginal bleeding and abdominal discomfort. The vaginal ultrasound showed an enlarged uterus size of 100 × 74 × 81 mm, with extended cavity with an unhomogenic content and myomas sized 54 × 69 mm located in fundus with secondary changes. She underwent abdominal hysterectomy with adnexectomy. Microscopic examination revealed submucosal uterine tumor with variabile histological organization that had anastomotic trabeculae with solid cellular grupations. Rare mitotic figures (2/10 HPF) were found. Additional imunohistochemistry showed immunophenotype: the sex cord areas were positive for vimentin(++), aSMA(++), AE1/AE3(+), PR(+), and ER(+). The poly phenotypic immunophenotype can be useful in differential diagnosis from other neoplasms but also suggests an origin of UTROSCT from uncommitted stem cell enabling for multidirectional differentiation.
Uterine tumors resembling ovarian sex-cord tumor